The server must have all updates installed.
It works just fine on the following configurations:

Windows 8, 8.1
Windows 7 x86 and x64
Windows 2008 x86 and x64 and R2
Windows 2012
Windows Vista (all x86 and x64 editions, with IIS 7.0 or better installed)
Windows XP Pro (with any Service Pack and updates, and IIS 5.0 or better)
Requires modern machine with at least 2Gb of memory and 2Ghz of CPU clock

Additional Information:

• No special rights needed to run, i.e. no need to add a user to debugger users group, etc.
   
• It does not use standard debugging technologies, that means
  No ports or dcom configuration or any other nonsense
   
• You don't even need to enable server side debugging with it! It should be disabled in fact.
  Therefore it doesn't block other users to browse your site and other developers to debug at the same time. It doesn't use standard technologies therefore it allows remote debugging and team remote debugging.